Ricerca partner per bando di Horizon Europe "Tools and technologies for a healthy society"

Call: Tools and technologies for a healthy society (HORIZON-HLTH-2024-TOOL-05-two-stage)

Project concept: to develop a tool that will allow us to study new drugs with pharmacological precision and model human heart atrium diseases

Partners involved:

• Institute of Human Genetics Polish Academy of Sciences, Poland (IHG PAS)
• Lukasiewicz Research Network – Poznan Institute of Technology, Poland (L-PIT)
• Ghent University, Belgium (UGENT)

Coordinator sought: preferably with experience in Extracellular Matrix compositions/hydrogels and able to develop/modify organ-on-chip chips and hardware

Partner sought and scope of the project:

1. Implementing bioprinting to achieve structural 3D organisation of the tissues

• Partner sought: a company 

2. Using different cell populations

• atrial and nodal Cardiomyocytes

Partner confirmed: UGENT, IHG PAS

• atrial Fibroblasts

Partner confirmed: IHG PAS

• Adipocytes to better mitigate tissue physiology 

3. Develop stable atrial-like extracellular matrix hydrogel system for tissue molding 

• Partner sought: a company/experts

4. Generate high-throughput chip-based system with pharmacological-grade drug dosing system and control

• Partner sought: an institute/company

Further proliferation with declared the Joint Research Center (in Belgium) validation and promotion of the results.

5. Develop an AI-based software to evaluate tissue responses in situ

• Partner confirmed: L-PIT

6. Additional to discuss:

• Clinical data – eg. Analysis of arrythmia patterns in AF (training of the AI + developing tissue architecture)
• Comparative studies with mouse models